MLB Picks — September 26, 2026

For MLB picks September 26, 2026, six games sit on the board with a clear lean toward the higher-confidence favorites. The Dodgers and White Sox headline the slate as five-star plays backed by model confidence of 89% and 80%, respectively. Today's MLB picks today emphasize moneyline bets where the pricing aligns with the strongest edges in the data. Lower-star selections still carry positive model support but warrant smaller sizing. Review each matchup for the single clearest advantage before placing action.

Dodgers vs Giants — Dodgers ML

Take the Dodgers ML at -325. This five-star selection carries the day's highest model confidence at 89%. The price reflects the Dodgers' overall superiority, and the model sees substantial value in laying the chalk here. No other edge on the board matches this level of conviction, making it the clearest play for your card. Size accordingly within your normal limits.

Rockies vs White Sox — White Sox ML

Back the White Sox ML at -230. Rated five stars with 80% model confidence, this bet stands out as the second-strongest lean. The market price lines up with the data's assessment of the White Sox as the clear side. Focus on this as a primary position alongside the Dodgers for the highest-conviction portion of the board.

Cardinals vs Brewers — Brewers ML

Play the Brewers ML at -190. This five-star pick shows 75% model confidence and represents a solid step down from the top two but still carries meaningful edge. The data favors the Brewers at the posted price, providing a reliable moneyline option that fits the day's overall favorite lean.

Angels vs Mariners — Mariners ML

Take the Mariners ML at -195. This three-star selection comes with 63% model confidence. The market price gives the Mariners the edge in the matchup, and the model supports the lean without reaching the conviction level of the five-star plays. Use it as a moderate-sized addition to the card.

Guardians vs Royals — Guardians ML

Play the Guardians ML at -125. Rated two stars with 60% model confidence, this is the lower end of the board's support. The data still points to the Guardians as the side to back at the listed price, though the margin is narrower than the higher-rated selections.

Mets vs Nationals — Mets ML

Back the Mets ML at -135. This two-star play also sits at 60% model confidence. The model edges toward the Mets on the moneyline, offering a modest lean that aligns with the rest of the day's favorite bias but requires disciplined sizing.

The board shows consistent model support across all six games, with the highest confidence clustered on the top three plays. Treat these percentages as directional guidance rather than guarantees. Manage your bankroll responsibly and only risk amounts you can afford to lose.